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Hypnotica was a class of somniferous drugs and substances tested in medicine of the 1890s and later, including: Urethan, Acetal, Methylal, Sulfonal, Paraldehyd, Amylenhydrate, Hypnon, Chloralurethan and Ohloralamid or Chloralimid.Research about using medications to treat insomnia evolved throughout the last half of the 20th century.Hydroxyzine has also been used to potentiate the analgesia of opioids and to alleviate some of their side effects, such as itching, nausea, and vomiting.Hydroxyzine preparations require a doctor's prescription. The drug is available in two formulations, the pamoate and the dihydrochloride or hydrochloride salts.And efforts on further improvement of the structure, based on the structure modification in the stomach due to the acid dissociation constant of the compound, led to the development of metiamide.Metiamide was an effective agent; however, it was associated with unacceptable nephrotoxicity and agranulocytosis.Early classes of drugs, such as barbiturates, have fallen out of use in most practices but are still prescribed for some patients.In children, prescribing hypnotics is not yet acceptable unless used to treat night terrors or somnambulism.

Levocetirizine is called a non-sedating antihistamine as it does not enter the brain in significant amounts, and is therefore unlikely to cause drowsiness.

It does not prevent the actual release of histamine from mast cells.

The manufacturers claim it to be more effective with fewer side effects than previous second-generation drugs; however, there have been no published studies supporting this assertion.

) is a first-generation antihistamine of the diphenylmethane and piperazine class.

It was first synthesized by Union Chimique Belge in 1956 and was marketed by Pfizer in the United States later the same year, and is still in widespread use today.

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